The 3D-Bioplotter® System is a suitable Rapid Prototyping tool for processing a great variety of biomaterials within the process of Computer Aided Tissue Engineering from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure.
Tissue Engineering and Controlled Drug Release require 3D scaffolds with well defined external and internal structures. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular Rapid Prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. The 3D-Bioplotter® is specially designed for work in sterile environments in a laminar flowbox, a requirement of Biofabrication, for example when using alginate cell suspensions for scaffold construction. In contrast to other Rapid Prototyping techniques, the 3D-Bioplotter® uses a very simple and straightforward technology, invented and developed at the Freiburg Materials Research Centre in Germany.
- 3-Axis positioning system with automatic tool changer
- Up to 5 different material cartridges can be used during the same build job
- Strand diameter is controlled via high resolution camera feedback
- Primary filter and sterile filter are included
- High temperature dispensing head (up to 250°C)
- Low temperature dispensing head (≈2°C to 70°C)
- Easy to use and easy to clean cartridge system
- Multi exchangeable base plate fixtures with heating and cooling capabilities (≈ 0°C to 65°C)
Fabrication Method and Hardening Process
Post-process sintering: Hydroxyapatite, TCP, Titanium
Precipitation: Chitosan, Collagen
2-component system: Alginate, Fibrin, PU, Silicone
Phase transition liquid – solid: Agar, Gelatine, PCL, PLGA, PLLA
The EnvisionTEC 3D-Bioplotter® 3D printing technique may be described as the deposition of multiple materials in three dimensions using pressure. Materials range from a viscous paste to a liquid, and are inserted using syringes moving in three dimensions. Air or mechanical pressure is applied to the syringe, which then deposits a strand of material for the length of movement and time the pressure is applied. Parallel strands are plotted in one layer. For the following layer, the direction of the strands is turned over the center of the object, creating a fine mesh with good mechanical properties and mathematically well-defined porosity.